Lena Pwerle grew up at Utopia Homestead, approximately 240km North East of Alice Springs with her siblings, Ray Loy, Cowboy Loy and Louie (Louis) Pwerle. Lena has also lived in other parts of the Utopia region, including Ngkwarlerlanem, where she lived with her family for many years. Initially Lena worked in the medium of batik, along with over eighty other women from the Utopia Region. Her work in batik is featured in the publication, 'Utopia A Picture Story'. In 1996 she was invited to represent Australia in Western Samoa for the Festival of Pacific Arts where she achieved critical acclaim. In the same year, she travelled to Indonesia for a workshop in batik, funded by the Northern Territory Department of Education. Lena has been working in acrylic since the 1990s and has maintained and developed a number of unique styles over the years.
A fine circular pattern of dots in the artist's works reflect Soakages (or waterholes) spread across her land. Unkempt arced motifs represent Awelye (women's ceremonial body paint designs). Short repetitive linear work accented with fine dots reflect Anwekety (conkerberry). Traditional colours of ochre reds, tawny yellows and soft whites, belonging to her country, Ahalpere, bequeath her early Soakage paintings and Awelye paintings with simplicity. Great mixes of colours are deliciously abundant in her Anwekety paintings and later Soakage works.